DOx^L is a simpler and faster version of DOx which is used to dock a given molecule within a pre-defined region of the docking site. DOx^Ldiffers from DOx in that DOx^L only attempts to optimise the position and orientation of a given molecule within a small box (typically a volume of around 8 ų) containing its centeroid. DOx^L therefore does not attempt a full docking, but optimises the positioning of a molecule against a selected scoring function. The current version of DOx^L can use either the PLP or XScore scoring functions.