Solutions

InhibOx has had extensive experience in assisting many different drug discovery projects, in both industry and academia. Each has presented a unique set of challenges and problems to be solved. By combining a variety of approaches and integrating many inputs we have created DrugFinder Lead and DrugFinder Refine, designed to maximize the chances of success in both lead discovery and lead optimization.

Lead Identification

As part of its DrugFinder initiative, InhibOx collaborated with the group of Dr. Angela Russell of the Departments of Pharmacology and Chemistry, at the University of Oxford. Taking an oncology kinase target as its starting point, InhibOx performed virtual screening of CSpace, using our database of commercially available moleculesand our proprietary software platform to identify inhibitors for experimental screening.

Subsequent experimental assays confirmed the identification of compounds of great interest, which are being actively pursued.

Read more about Lead Identification and DrugFinder.

Lead Optimization

InhibOx carried out a lead optimization project with Lauras AS, a Norwegian biotechnology company, to help advance its drug discovery pipeline.

Starting from the existing SAR and available structural data, InhibOx used its proprietary virtual screening platform and expertise to derive structural and QSAR models which rationalized the activity of the known leads and identified novel compounds for synthesis.

In addition to novelty, these new compounds offer other potential advantages over previously existing leads.

“InhibOx has helped redesign the company’s drug targeting programme, and suggested new lines of derivitization that have delivered compounds with the properties we wanted. The competence InhibOx provides and the quality of what they deliver is exceptional.”

—Kjetil Tasken, Lauras VP R&D